Parkinson's Disease OVERVIEW Parkinson’s disease (PD) is a slowly progressive, degenerative neurologic disorder that affects muscle control. It is caused by the degeneration of a part of the brain called the substantia nigra. This region of the brain is responsible for the production of the neurotransmitter, dopamine. Reduced dopamine production leads to reduced activation of the nerve cells responsible for normal muscle activity. Symptoms may start with infrequent blinking, lack of facial expression, and deliberateness of speech, then progress to trembling of the arms and legs, muscular rigidity, and poor balance, and finally resulting in the inability to walk or talk, paranoia, delirium, and dementia. The cause of Parkinson’s disease is unknown, but possible factors include genetics, exposure to environmental poisons (pesticides and insecticides, carbon monoxide, carbon disulfide, manganese), viral infection, head trauma, free radicals, and some medications. SUPPLEMENTS FOR PARKINSON'S DISEASE* There are many natural supplements that may help with Parkinson's Disease. Consult with your healthcare provider to see which of the following supplements may be appropriate for you. *PLEASE NOTE: It is very important to make sure that supplements do not interfere with your medications or an existing health condition. First check with your doctor before trying any supplements. Vitamins & Minerals Vitamin E – A higher intake of the natural form of this fat-soluble vitamin is associated with a decreased incidence of Parkinson's. The synthetic form may not be helpful. Less Helpful: choline (CDP or GPC), vitamin C, vitamin D. Other Supplements Creatine – Supplementing with this high-energy molecule may slow the progression of PD and also increase exercise tolerance. CoQ10 – This coenzyme is a link in the electron transport chain, where the high-energy molecule, ATP, is manufactured. Several studies have shown that supplementing with CoQ10 may slow the functional decline in Parkinson's patients. Octacosanol – Classified as a waxy alcohol found in wheat germ, octacosanol may improve symptoms associated with PD. Phenylalanine – Supplementing with this essential amino acid (EAA) may sometimes reduce Parkinson's symptoms. Less Helpful: tyrosine. Herbs Green Tea – Consuming green tea and other caffeinated beverages (black tea, coffee) may prevent or delay the onset of Parkinson's Disease. COMMENTS Treatment includes medications (L-dopa or levodopa, dopamine agonists, anticholinergics, antidepressants), physical therapy, and surgery. Drinking caffeinated beverages (coffee, cola, tea) reduces the risk for PD. Exercise regularly, such as walking. It is very important to stretch the muscles, making yoga very helpful. References Jellin, JM, editor. Natural Medicines Comprehensive Database, 2008. Pillepich, JA. The Nutraceutical Reference Guide, 2005. FOR PARKINSON'S DISEASE, CONSIDER THESE SUPPLEMENTS* ● E-400 ● Brain Energy ● CoQ10 ● Green Tea *First check with your doctor if you have a medical condition or are taking prescription medications. * * * * * * Total Health Nutrients is a multi-faceted company, with operations in New York and New Jersey. We provide both services and products, such as: Nutritional Supplements: We carry the highest quality supplements to speed up your healing process. They were developed to contain the right proportions of vitamins, minerals, and essential fatty acids, without danger of toxic build-up and without dangerous side effects. Each ingredient is selected in consideration of its absorbability, competitive relationship with other nutrients, allergenic potential, and long-term safety. Also, our supplements are manufactured in a cGMP (current Good Manufacturing Practices) facility, ensuring you always get a pure product that meets label potency. Go to www.totalhealthnutrients.com to check out our selection of pure supplements. Personalized Vitamin Organizers: As an added service, we offer these compartmentalized containers filled with your supplement regimen, with each section labeled, for easy identification. For people who are rushed in the morning or who travel frequently, this service makes life a bit less complicated. Dietary Analysis: We use the most reliable computerized nutritional analysis program available. More than 29,000 foods, from all food groups, are accessed by our computer program, analyzing a person's usual dietary intake. The resulting reports provide the information in tabular and graphical formats. Metabolic Testing: This service measures how many calories you burn at various activities, and how many calories you need daily to lose/sustain/or increase your weight, depending on your goals. Having these numbers enables us to make your personalized plan as accurate as possible. TSFL Weight Loss Program: We proudly feature TSFL Weight Loss Program for patients that need to lose weight as quickly and safely as possible. Clinically proven by Johns Hopkins University - Take Shape For Life will help you reach your weight goal with Medifast Meals that are low calorie, low fat, and nutritionally balanced. There is no counting calories, carbs, or points. It is all done for you. Along the way, we will provide the care and support you need to succeed in maintaining your weight loss and health program for life. More info is available at www.rainbowdiet.tsfl.com. 1-888-THN-7284 www.totalhealthnutrients.com Call Total Health Nutrients today, or visit our web site, for our great selection of high-quality nutritional supplements! Helpful Natural Supplements and Treatments

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