Coenzyme Q10: Heart Healthy and More

DESCRIPTION/FUNCTION

There are many metabolic pathways in the body. One is the electron transport chain, where CoQ10 facilitates electron flow. The electron transport chain enables oxidative phosphorylation, which produces adenosine triphosphate (ATP), often described as the energy currency of the body. CoQ10 is also a fat‑soluble antioxidant. Another name for coenzyme Q is ubiquinone, because it is a quinone (a chemical class that also includes vitamins E and K), and it is ubiquitous (it is found in almost all animal cells).

RDA (Recommended Dietary Allowance) for Adults

None.

MAJOR SOURCES

Made in the body and nutritional supplements.

MAINTENANCE/THERAPEUTIC RANGE

25 mg to 1,200 mg. (Therapeutic dosages range from 100 mg to 400 mg, except for Parkinson=s Disease at 1,200 mg.)

POSSIBLE THERAPEUTIC APPLICATIONS

Angina pectoris; cancer (breast); cardiomyopathy; congestive heart failure; diabetes; gum disease; headache (migraine); high blood pressure; high cholesterol; HIV/AIDS; infertility (male); mitral valve prolapse; Parkinson=s disease.

COMMENTS

Many statin‑class cholesterol lowering drugs reduce the body=s production of CoQ10, and therefore increase the need for its supplementation. CoQ10 is particularly helpful for the heart because it is a high-energy molecule, and the heart is an organ requiring a lot of energy. Like vitamin E, CoQ10 is fat-soluble and should be taken with food.

CAUTIONS

None significant. There was concern that CoQ10 might interfere with warfarin (Coumadin), but that does not appear to be the case. If you are taking it for congestive heart failure, do not abruptly stop taking it.

References
Jellin, JM, editor. Natural Medicines Comprehensive Database, 2005.
Pillepich, JA. The Nutraceutical Reference Guide, 2005.

For COQ10 supplementation, TRY:

CoQ10 (100 mg)

CoQ10 (200 mg)

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