L-Tryptophan DESCRIPTION/FUNCTION Tryptophan is classified as an essential amino acid. It is necessary for normal growth in infants, and for nitrogen balance in adults. Tryptophan can be converted into several substances, including 5-HTP (5-hydroxytryptophan) and the inhibitory neurotransmitter, serotonin. Serotonin is then converted to the hormone, melatonin. Tryptophan can be converted into the B-vitamin, niacin (60 mg tryptophan = 1 mg niacin). Tryptophan is also converted to picolinic acid, which can help with chromium and zinc absorption. RDA (Recommended Dietary Allowance) for Adults 3.5 mg/kg/day. MAJOR SOURCES Protein foods, especially legumes, grains, and seeds. MAINTENANCE/THERAPEUTIC RANGE 500 mg to 2,000 mg. POSSIBLE THERAPEUTIC APPLICATIONS Depression, fibromyalgia, insomnia, premenstrual syndrome. COMMENTS Tryptophan used to be difficult to obtain, and most people had switched to 5-HTP instead. That was because one contaminated batch produced by a Japanese manufacturer in 1989 resulted in more than 1,000 cases of eosinophilia-myalgia syndrome. Consequently, the FDA had restricted the sale of tryptophan. However, tryptophan is available again, and some vitamin companies are now selling it. As a sleep aid, it should be taken 30 min. to 45 min. before bed. It works better when taken with a simple carbohydrate (for example, fruit juice) and a small amount of vitamin B6. As with all amino acids, supplements should be taken on an empty stomach, or at least separate from protein foods. CAUTIONS Avoid if pregnant. Consult with your health practitioner if you are taking medication for depression. References Jellin, JM, editor. Natural Medicines Comprehensive Database, 2007. Pillepich, JA. The Nutraceutical Reference Guide, 2005. FOR TRYPTOPHAN, CONSIDER THIS SUPPLEMENT: ● L-Tryptophan The products and the claims made about specific products on or through this site have not been evaluated by the United States Food and Drug Administration and are not intended to diagnose, treat, cure or prevent disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professionals or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. 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